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Carcinogenesis Inside a life time carcinogenicity research performed in B6C3F1 mice, methylphenidate induced a rise in hepatocellular adenomas, and in males only, a rise in hepatoblastomas in a daily dose of around sixty mg/kg/working day. This dose is about 2 times the MRHD of 60 mg/working day offered to young children on mg/m2 foundation.Circle